Skip to main content
. 2023 Sep 16;14:5749. doi: 10.1038/s41467-023-41502-4

Fig. 7. Adult cKO mice display a significant decrease in the content of synaptic markers in the hippocampus.

Fig. 7

a Representative western blots of synaptic markers in hippocampal homogenate from 7–8 months old control and cKO littermates and b relative quantification, normalized to the control group. Each data point corresponds to one animal. Control: N = 4 males; N = 5 females; cKO: N = 4 males; N = 3 females. Two-tailed unpaired t test, *p(VGLUT1) = 0.0307; **p(PSD95) = 0.0010; **p(Gephyrin) = 0.0072; *p(GluA2) = 0.0101. c Representative confocal z-stack projections of PSD95 puncta in the CA1 stratum radiatum from adult control and cKO mice (7–8 months). Scale bar: 10 µm. d Quantification of the area covered by PSD95-positive puncta, normalized to controls. Each data point corresponds to one animal. Control: N = 4 males; N = 5 females; cKO: N = 4 males; N = 3 females. Two-tailed unpaired t test, **p = 0.0038. b, d Source data are provided as a Source Data file.