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. 2023 Sep 16;7:93. doi: 10.1038/s41698-023-00447-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Heatmap of membrane proteins expression in six human CCA cell lines and normal 293T cells. b Flow cytometry analysis of cell membrane expression levels of ICAM1 in six CCA cell lines and normal 293T cells. c IF staining of ICAM1 in human CCA and normal 293T cells. Scale bar, 20 µm. d, e ICAM1 mRNA expression levels of human CCA tumor tissues and normal bile duct tissues in TCGA samples acquired from UALCAN website. Error bars, SD. Unpaired t-test, ***P < 0.001, ****P < 0.0001. Median, quartiles, minimum, and maximum values are represented by the central line, limits of box, and ends of lines of boxplots shown. f Representative images of IHC staining of ICAM1 in human CCA tumor tissues (iCCA and eCCA) and normal bile duct tissues. Scale bar, 200 µm. g ICAM1 positive proportion in tumor and adjacent normal tissues in CCA patients (N = 78). h ICAM1 positive proportion in tumor tissues of iCCA (N = 47) and eCCA (N = 31) patients.