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. 2023 Sep 16;7:93. doi: 10.1038/s41698-023-00447-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Schematic diagram of the structure of an ICAM1-DXd. b Schematic diagram of the structure of an ICAM1-MMAE. c In vitro cytotoxicity of ICAM1 antibody (ICAM1 mAb), two ICAM1 ADCs (ICAM1-MMAE and ICAM1-DXd), and one chemotherapy drug Gemcitabine against a panel of six human CCA cell lines and normal 293T cells.