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. 2023 Sep 16;7:93. doi: 10.1038/s41698-023-00447-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Schematic design of CCA biodistribution study in a CCA tumor (HuCCT1) xenografted model. b In vivo NIR fluorescent images of nude mice at 48 h after the administration of IgG-Cy5.5, ICAM1-Cy5.5, and ICAM1-MMAE-Cy5.5 (N = 5 per group). c Representative ex vivo NIR fluorescent images of HuCCT1 tumor and six major organs (heart, liver, spleen, lung, kidney, and brain). d Quantified normal organ distribution of IgG-Cy5.5, ICAM1-Cy5.5, and ICAM1-MMAE-Cy5.5 (N = 5). e Quantified HuCCT1 tumor accumulation of IgG-Cy5.5, ICAM1-Cy5.5, and ICAM1-MMAE-Cy5.5 (N = 5 per group). Unpaired t-test, ****P < 0.0001, ns not significant. Error bars, SD. Median, quartiles, minimum, and maximum values are represented by the central line, limits of box, and ends of lines of boxplots shown.