19q loss increased the risk of specific pathological high-risk factors (A) Composite SCNA profile of cfDNA collected from the AH of enucleated eyes with or without massive choroid invasion (B) Composite SCNA profile of cfDNA collected from the AH of enucleated eyes with or without postlaminar ON invasion. AH, aqueous humour; cfDNA, cell-free DNA, ON, optic nerve; SCNA, somatic copy number alteration.