. Author manuscript; available in PMC: 2024 Aug 1.

Published in final edited form as: Fundam Clin Pharmacol. 2023 Mar 25;37(4):726–738. doi: 10.1111/fcp.12889

Table 4.

Metabolism pathways

Pathway	Molnupiravir	Nirmatrelvir	Remdesivir
Hydrolysis	Yes	Yes^*	Yes
Oxidation		Yes	Yes
Significance (hydrolysis)	Activation		Activation
Significance (oxidation)		Inactivation	TBD

Via bacteria in the gastrointestinal tract [96]. TBD: to be determined.