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. Author manuscript; available in PMC: 2024 Aug 1.
Published in final edited form as: Adv Healthc Mater. 2023 Apr 2;12(20):e2300584. doi: 10.1002/adhm.202300584

Figure 5. Perfusion bioreactor culture improves healing in a diabetic mouse excisional wound healing model.

Figure 5.

(A) Closure evaluated for wounds treated with flask MSC EVs, bioreactor MSC EVs, or PBS. Bioreactor MSC EVs improved overall wound healing compared with the PBS control (p < 0.05). (B) Representative images of mice wounds over the length of the experiment. (C) Number of CD31+ vessels in healed tissues isolated from mice on day 21 with (D) representative immunohistochemistry images. A significant enhancement of CD31+ vessels was apparent in mice treated with bioreactor MSC EVs (p < 0.05). Statistical significance was calculated using a (A) two-way ANOVA or (C) one-way ANOVA with Holm- Šídák’s multiple comparisons test (*p < 0.05; n = 8).