Table 3.
Associations of different classes of change in TyG-BMI with stroke incidence stratified by different factors
| Subgroup | Change in the TyG-BMI, OR (95% CI) | P for interaction | |||
|---|---|---|---|---|---|
| Class 1 (n = 1273) | Class 2 (n = 1664) | Class 3 (n = 1171) | Class 4 (n = 475) | ||
| Age (years) | 0.192 | ||||
| < 60 | Reference | 1.22 (0.59–2.54) | 2.07 (1.09–3.93) | 2.65 (1.18–5.92) | |
| ≥ 60 | Reference | 0.92 (0.52–1.64) | 1.45 (0.91–2.28) | 1.16 (0.54–2.51) | |
| Sex | 0.919 | ||||
| Male | Reference | 1.16 (0.60–2.25) | 1.54 (0.92–2.59) | 1.83 (0.78–4.30) | |
| Female | Reference | 0.88 (0.47–1.62) | 1.60 (0.93–2.73) | 1.63 (0.82–3.25) | |
| Marital status | 0.122 | ||||
| Married | Reference | 1.25 (0.74–2.09) | 1.95 (1.25–3.04) | 1.90 (1.04–3.45) | |
| Other | Reference | 0.49 (0.18–1.33) | 1.08 (0.53–2.17) | 1.45 (0.41–5.19) | |
| Residence | 0.319 | ||||
| Urban | Reference | 0.93 (0.34–2.59) | 2.49 (0.99–6.26) | 1.79 (0.58–5.50) | |
| Rural | Reference | 1.07 (0.65–1.78) | 1.42 (0.94–2.14) | 1.60 (0.86–2.98) | |
| Educational level | 0.153 | ||||
| No formal education | Reference | 0.80 (0.37–1.73) | 1.15 (0.63–2.10) | 1.35 (0.53–3.43) | |
| Primary school | Reference | 1.03 (0.53–2.02) | 1.84 (1.06–3.20) | 1.57 (0.68–3.59) | |
| Middle or high school | Reference | 2.50 (0.75–8.31) | 3.64 (1.19–11.16) | 4.46 (1.19–16.69) | |
| College or above | Reference | NA | NA | NA | |
| Smoking status | 0.999 | ||||
| Never | Reference | 0.91 (0.51–1.65) | 1.59 (0.95–2.66) | 1.62 (0.82–3.19) | |
| Former | Reference | 0.95 (0.24–3.75) | 1.29 (0.42–4.00) | 2.16 (0.43–10.78) | |
| Current | Reference | 1.29 (0.55–3.00) | 1.60 (0.85–2.99) | 1.88 (0.64–5.50) | |
| Drinking status | 0.860 | ||||
| Never | Reference | 0.99 (0.56–1.77) | 1.48 (0.90–2.44) | 1.42 (0.72–2.83) | |
| Former | Reference | 0.52 (0.12–2.21) | 1.23 (0.39–3.88) | 0.76 (0.11–5.52) | |
| Current | Reference | 1.12 (0.49–2.57) | 1.87 (0.98–3.58) | 2.46 (0.92–6.56) | |
| Hypertension | 0.540 | ||||
| No | Reference | 1.03 (0.58–1.83) | 1.49 (0.97–2.29) | 2.06 (1.00–4.27) | |
| Yes | Reference | 1.20 (0.53–2.74) | 2.24 (1.04–4.83) | 1.78 (0.72–4.39) | |
| Diabetes | 0.556 | ||||
| No | Reference | 1.01 (0.64–1.59) | 1.65 (1.14–2.39) | 1.73 (0.99–3.02) | |
| Yes | Reference | 0.75 (0.06–9.83) | 0.72 (0.06–9.34) | 1.09 (0.07–15.94) | |
| Heart disease | 0.752 | ||||
| No | Reference | 0.96 (0.59–1.56) | 1.50 (1.02–2.23) | 1.74 (0.98–3.10) | |
| Yes | Reference | 1.12 (0.34–3.75) | 2.23 (0.76–6.60) | 1.67 (0.43–6.44) | |
| Dyslipidaemia | 0.529 | ||||
| No | Reference | 0.91 (0.57–1.46) | 1.54 (1.05–2.25) | 1.79 (1.00–3.22) | |
| Yes | Reference | 2.68 (0.31–23.49) | 3.99 (0.47–33.50) | 3.73 (0.40–34.69) | |
| Kidney disease | 0.865 | ||||
| No | Reference | 0.94 (0.60–1.49) | 1.55 (1.06–2.26) | 1.68 (0.98–2.88) | |
| Yes | Reference | 2.20 (0.31–15.64) | 3.22 (0.49–21.26) | 3.22 (0.24–43.38) | |
BMI: body mass index; CI: confidence interval; OR: odds ratio; TyG: triglyceride-glucose; NA: not applicable
All models were adjusted for age, sex, marital status, residence, educational level, smoking status, drinking status, history of hypertension, diabetes, heart disease, dyslipidaemia, kidney disease, medication use for hypertension, medication use for diabetes, medication use for dyslipidaemia, systolic blood pressure, diastolic blood pressure, total cholesterol, HDL-C, LDL-C, HbA1c, and the eGFR