Table 4.
Associations of the cumulative TyG-BMI with stroke stratified by different factors
| Subgroup | Cumulative TyG-BMI, OR (95% CI) | P for trenda | P for interaction | |||
|---|---|---|---|---|---|---|
| Quartile 1 [353, 534] |
Quartile 2 (534, 608] |
Quartile 3 (608, 693] |
Quartile 4 (693, 1130] |
|||
| Age (years) | 0.151 | |||||
| < 60 | Reference | 2.59 (1.20–5.56) | 2.14 (0.97–4.70) | 2.43 (1.07–5.49) | 0.188 | |
| ≥ 60 | Reference | 1.41 (0.86–2.32) | 1.20 (0.70–2.08) | 0.96 (0.51–1.81) | 0.735 | |
| Sex | 0.354 | |||||
| Male | Reference | 1.74 (0.97–3.12) | 2.12 (1.14–3.94) | 1.41 (0.66–3.01) | 0.339 | |
| Female | Reference | 1.46 (0.82–2.60) | 0.93 (0.51–1.72) | 1.14 (0.61–2.14) | 0.860 | |
| Marital status | 0.008 | |||||
| Married | Reference | 2.04 (1.22–3.39) | 2.04 (1.21–3.44) | 1.76 (1.00–3.10) | 0.256 | |
| Other | Reference | 1.25 (0.60–2.58) | 0.42 (0.15–1.17) | 0.65 (0.23–1.78) | 0.219 | |
| Residence | 0.720 | |||||
| Urban | Reference | 2.11 (0.75–5.95) | 1.52 (0.54–4.32) | 1.06 (0.35–3.22) | 0.285 | |
| Rural | Reference | 1.53 (0.97–2.40) | 1.39 (0.85–2.27) | 1.43 (0.83–2.45) | 0.337 | |
| Educational level | 0.034 | |||||
| No formal education | Reference | 1.19 (0.61–2.33) | 0.93 (0.44–1.97) | 1.33 (0.60–2.96) | 0.564 | |
| Primary school | Reference | 1.64 (0.89–3.04) | 1.69 (0.89–3.22) | 1.23 (0.59–2.54) | 0.863 | |
| Middle or high school | Reference | 6.49 (1.44–29.29) | 5.13 (1.12–23.55) | 4.56 (0.94–22.07) | 0.464 | |
| College or above | Reference | NA | NA | NA | NA | |
| Smoking status | 0.483 | |||||
| Never | Reference | 1.54 (0.88–2.69) | 1.00 (0.55–1.81) | 1.20 (0.65–2.21) | 0.924 | |
| Former | Reference | 0.89 (0.23–3.43) | 1.85 (0.52–6.63) | 1.57 (0.36–6.84) | 0.444 | |
| Current | Reference | 1.91 (0.96–3.83) | 2.33 (1.09–4.96) | 1.23 (0.46–3.26) | 0.476 | |
| Drinking status | 0.906 | |||||
| Never | Reference | 1.55 (0.89–2.70) | 1.30 (0.72–2.32) | 1.26 (0.68–2.35) | 0.865 | |
| Former | Reference | 1.61 (0.47–5.48) | 0.65 (0.16–2.68) | 0.75 (0.16–3.62) | 0.503 | |
| Current | Reference | 1.83 (0.90–3.74) | 1.90 (0.88–4.12) | 1.72 (0.71–4.16) | 0.307 | |
| Hypertension | 0.241 | |||||
| No | Reference | 1.40 (0.87–2.25) | 1.39 (0.82–2.35) | 1.51 (0.83–2.74) | 0.209 | |
| Yes | Reference | 3.24 (1.27–8.25) | 2.16 (0.85–5.53) | 1.82 (0.69–4.80) | 0.644 | |
| Diabetes | 0.333 | |||||
| No | Reference | 1.69 (1.12–2.56) | 1.49 (0.96–2.31) | 1.38 (0.84–2.26) | 0.479 | |
| Yes | Reference | 1.00 (0.07–14.33) | 0.24 (0.01–4.70) | 0.78 (0.05–11.40) | 0.927 | |
| Heart disease | 0.709 | |||||
| No | Reference | 1.53 (0.99–2.36) | 1.36 (0.85–2.16) | 1.32 (0.79–2.20) | 0.535 | |
| Yes | Reference | 2.52 (0.74–8.58) | 1.58 (0.44–5.72) | 1.62 (0.44–6.00) | 0.991 | |
| Dyslipidaemia | 0.591 | |||||
| No | Reference | 1.59 (1.05–2.43) | 1.38 (0.88–2.18) | 1.28 (0.77–2.12) | 0.626 | |
| Yes | Reference | 4.38 (0.49–38.93) | 2.78 (0.32–24.24) | 2.92 (0.33–25.81) | 0.983 | |
| Kidney disease | 0.066 | |||||
| No | Reference | 1.48 (0.97–2.24) | 1.30 (0.84–2.02) | 1.26 (0.78–2.04) | 0.659 | 0.151 |
| Yes | Reference | NA | NA | NA | NA | |
BMI: body mass index; CI: confidence interval; OR: odds ratio; TyG: triglyceride-glucose; NA: not applicable
All models were adjusted for age, sex, marital status, residence, educational level, smoking status, drinking status, history of hypertension, diabetes, heart disease, dyslipidaemia, kidney disease, medication use for hypertension, medication use for diabetes, medication use for dyslipidaemia, systolic blood pressure, diastolic blood pressure, total cholesterol, HDL-C, LDL-C, HbA1c, and the eGFR
aTests for linear trends were performed by modelling the median value of each quantile to test ordered relations across quantiles of cumulative TyG-BMI