Table 1.
Study Participant Characteristics for CAH and Control Infants
CAH (n = 16) | Control (n = 14) | Group Difference, p-value | |
---|---|---|---|
Age at MRI (weeks) | |||
Gestational Age | 38.2 ± 1.74 | 38.5 ± 1.8 | 0.83a |
Post-conceptional Age | 42.2 ± 3.0 | 42.5 ± 2.4 | 0.88a |
Biological sex (n) | Female, 8 Male, 8 | Female, 5 Male, 9 | 0.68b |
Hispanic/ Latino (n; %) | 6; 37.5% | 7; 50% | 0.79b |
Race (n; %) | |||
White | 14; 87.5% | 5; 35.7% | 0.001b |
Asian | 2; 12.5% | 2; 14.3% | |
CAH Form (n) | |||
Salt-wasting | 15 | - | - |
Simple-virilizing | 1 | ||
Glucocorticoid dose (mg/m2/day) | 35.2 ± 16.4 | - | - |
Fludrocortisone dose (mg/day) | 0.12 ± 0.04 | ||
NaCl dose (mEq/day) | 4.27 ± 0.70 | ||
CAH Analytes | |||
Newborn screen 17-OHP (ng/dL) | 29080.4 ± 14325.2 | - | - |
Newborn screen 17-OHP [nmol/L] | [881.1 ± 434.1] | ||
Confirmatory serum 17-OHP (ng/dL) | 16719.8 ± 11164.5 | ||
Confirmatory serum 17-OHP [nmol/L] | [506.6 ± 338.3] | ||
Highest newborn 17-OHP (ng/dL) | 28861.9 ± 13996.9 | ||
Highest newborn 17-OHP [nmol/L] | [874.5 ± 424.1] | ||
Confirmatory serum testosterone (ng/dL) | 289.1 ± 277.7 | ||
Confirmatory serum testosterone [nmol/L] | [10.03 ± 9.6] | ||
Confirmatory serum androstenedione (ng/dL) | 3674.6 ± 3699.8 | ||
Confirmatory serum androstenedione [nmol/L] | [128.2 ± 129.1] | ||
Plasma Renin Activity (ng/mL/hr and μg/L/hr) | 50.1 ± 75.4 |
Mean ± SD
Wilcoxon sign-rank test;
Chi-square test