Table 2.
Brain Volume Comparisons between CAH and Control Infants
| CAH | Controls | ||||
|---|---|---|---|---|---|
| Region | Volume (mm3) | 95% CI | Volume (mm3) | 95% CI | |
| TBV | Raw | 390672 | (371064, 410281) | 393126 | (371747, 414506) |
| Frontal | Raw | 120,293 | (113015, 127571) | 119,799 | (111864,127734) |
| TBV Adjusted† | 121,273 | (120164,122381) | 120,006 | (118799, 121212) | |
| Parietal | Raw | 74,717 | (70077, 79357) | 76,307 | (71248, 81366) |
| TBV Adjusted† | 75,335 | (74356, 76314) | 76,438 | (75373, 77503) | |
| Occipital | Raw | 51,438 | (47980, 54895) | 52,294 | (48524, 56063) |
| TBV Adjusted | 51,890 | (50918, 52863) | 52,389 | (51331, 53448) | |
| Temporal | Raw | 66,293 | (62355, 70231) | 65,505 | (61211, 69799) |
| TBV Adjusted * | 66,817 | (65957, 67677) | 65,616 | (64680, 66551) | |
| Limbic | Raw | 19,572 | (18254, 20890) | 19,634 | (18197, 21071) |
| TBV Adjusted | 19,743 | (19325, 20160) | 19,670 | (19216, 20125) | |
| Cerebellum | Raw | 26,404 | (24715, 28093) | 26,936 | (25095, 28777) |
| TBV Adjusted | 26,574 | (25418, 27730) | 26,972 | (25714, 28230) | |
| Thalamus | Raw * | 8,606 | (8209, 9002) | 9,215 | (8783, 9647) |
| TBV Adjusted ** | 8,646 | (8373, 8918) | 9,223 | (8927, 9519) | |
| LV | Raw | 5,399 | (4590, 6209) | 4,766 | (3883, 5649) |
| TBV Adjusted | 5,451 | (4721, 6181) | 4,777 | (3982, 5571) | |
| Corpus Callosum | Raw | 2,597 | (2386, 2808) | 2,566 | (2336, 2796) |
| TBV Adjusted | 2,620 | (2496, 2744) | 2,571 | (2436, 2706) | |
| Brainstem | Raw | 6,044 | (5717, 6371) | 6,207 | (5851, 6564) |
| TBV Adjusted | 6,075 | (5837, 6314) | 6,214 | (5955, 6473) | |
Abbreviations: CAH, congenital adrenal hyperplasia; CI, confidence interval; TBV, total brain volume; LV, lateral ventricles
All regressions (Raw, TBV Adjusted) were adjusted for post-conceptional age and sex.
†
0.05 < p < 0.10;
*
p < 0.05;
**
p < 0.01