Table 3.
The Frequency of NAT2 Genetic Alleles Among a Sample of Jordanian T2DM and Non-T2DM Subjects
| NAT2 Allele | Nucleic acid Changea | Reference ID | Amino Acid Change | Acetylation Activity | Proportion in Non-T2DM | Proportion in T2DM | P-value |
|---|---|---|---|---|---|---|---|
| NAT2*13 | 282 C>T | rs1041983 | Tyr94Tyr | High | 0.27 | 0.49 | 0.018* |
| NAT2*5 | T341 T>C | rs1801280 | Ile114Thr | Decreased | 0.49 | 0.33 | 0.095 |
| NAT2*11 | 481C>T | rs1799929 | Leu161Leu | High | 0.35 | 0.31 | 0.661 |
| NAT2*6 | 590 G>A | rs1799930 | Arg197Glin | Decreased | 0.31 | 0.46 | 0.582 |
| NAT2*12 | 803 A>G | rs1208 | Arg268Lys | High | 0.32 | 0.32 | 0.912 |
| NAT2*7 | 857A>G | rs1799931 | Gly286Glu | Decreased | 0 | 0.06 | 0.043* |
Notes: aThe reference sequence used was GenBank accession No. NC_000008.11, and the position is indicated in respect to the start codon ATG NAT2 gene; the A in ATG is + 1. “T2DM” is the abbreviation of type II diabetes mellitus, and NAT2 is the abbreviation of N-acetyltransferase 2 gene. *Indicates a statistically significant P value when it is less than 0.05.