Table 1.
The Association Between Clinic Pathologic Features and EGFR Mutations
| Clinical Factors | All (N = 110) | EGFR+ (N = 48) | EGFR− (N = 62) | P |
|---|---|---|---|---|
| Gender, N (%) | <0.001 | |||
| Male | 65 (59.1) | 19(39.6) | 46(74.2) | |
| Female | 45 (40.9) | 29(60.4) | 16(25.8) | |
| Age, N (%) | 0.202 | |||
| <65 | 43 (39.1) | 22(45.8) | 21(33.9) | |
| ≥65 | 67 (60.9) | 26(54.2) | 41(66.1) | |
| Tumor location, N (%) | 0.099 | |||
| Left | 38 (34.5) | 16(33.3) | 22(35.5) | |
| Right | 65 (59.1) | 32(66.7) | 33(53.2) | |
| Bilateral | 2 (1.8) | 0(0) | 2(3.2) | |
| Weasand | 5 (4.5) | 0(0) | 5(8.1) | |
| Histology, N (%) | <0.001 | |||
| Adenocarcinoma | 96 (87.3) | 48(100) | 48(77.4) | |
| Squamous carcinoma | 14 (12.7) | 0(0) | 14(22.6) | |
| Metastasis I, N (%) | 0.035 | |||
| Intrathoracic | 86 (78.2) | 33(68.8) | 53(85.5) | |
| Extrathoracic | 24 (21.8) | 15(31.3) | 9(14.5) | |
| Metastasis II, N (%) | 0.102 | |||
| Intracranial | 18 (16.4) | 11(22.9) | 7(11.3) | |
| Extracranial | 92 (83.6) | 37(77.1) | 55(88.7) | |
| CEA, N (%) | 0.011 | |||
| <10 | 47 (42.7) | 13(27.1) | 34(54.8) | |
| 10–100 | 38 (34.5) | 18(37.5) | 20(32.3) | |
| 101–1000 | 18 (16.4) | 12(25) | 6(9.7) | |
| >1000 | 7 (6.4) | 5(10.4) | 2(3.2) | |
| Smoking history, N (%) | 0.001 | |||
| Absent | 71 (64.5) | 39(81.3) | 32(51.6) | |
| Present | 39 (35.5) | 9(18.8) | 30(48.4) |
Abbreviations: EGFR, epidermal growth factor receptor; CEA, carcinoembryonic antigen; EGFR+, EGFR mutation; EGFR−, EGFR wild-type.