TABLE 1.
Pooled mean differences of different types of antihypertensive drugs on pulse wave velocity. Upper right triangle gives the pooled mean differences from pairwise comparisons (column intervention relative to row), lower left triangle pooled mean differences from the network meta-analysis (row intervention relative to column). * Values p < 0.05 were considered significant.
| PB | −0.48 (−0.98, 0.02) n1 = 1/n2 = 48 | 0.07 (−0.38, 0.51) n1 = 1/n2 = 79 | −0.39 (−0.76, −0.02) n1 = 1/n2 = 115 | −1.15
(−2.13, −0.18) n1 = 3/n2 = 126 |
0.01 (−0.47, 0.49) n1 = 1/n2 = 68 |
−0.36 (−0.72, 0.01) n1 = 2/n2 = 85 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| −0.49 (−0.91, −0.07) | BB | 0.09 (−0.30, 0.47) n1 = 3/n2 = 106 | NA | −0.24 (−0.47, −0.01) n1 = 8/n2 = 281 | 0.12 (−0.07, 0.30) n1 = 6/n2 = 456 | −0.05 (−0.51, 0.41) n1 = 4/n2 = 135 | −0.46 (−0.93, 0.02) n1 = 1/n2 = 52 |
NA | −0.34 (−0.71, 0.03) n1 = 1/n2 = 114 | NA | 0.02 (−0.15, 0.20) n1 = 3/n2 = 1019 | NA | NA | NA | NA |
| −0.42 (−0.86, 0.03) | 0.08 (−0.27, 0.43) | TD | NA | −0.30 (−0.65, 0.05) n1 = 5/n2 = 221 | −0.04 (−0.35, 0.28) n1 = 3/n2 = 153 | −0.17 (−0.41, 0.07) n1 = 5/n2 = 196 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| −0.50 (−1.21, 0.22) | −0.00 (−0.75, 0.75) | −0.08 (−0.85, 0.69) | AAD | NA | NA | −0.20 (−0.54, 0.14) n1 = 1/n2 = 139 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| −0.68 (−1.08, −0.29) | −0.19 (−0.46, 0.08) | −0.27 (−0.59, 0.06) | −0.19 (−0.93, 0.55) | ACEI | −0.06 (−0.48, 0.35) n1 = 9/n2 = 448 | 0.20 (−0.04, 0.44) n1 = 8/n2 = 319 | 0.03 (−0.39, 0.45) n1 = 2/n2 = 88 | 0.15 (−0.35, 0.66) n1 = 1/n2 = 58 | NA | NA | NA | NA | −1.76 (−3.04, −0.48) n1 = 2/n2 = 45 | NA | NA |
| −0.59 (−0.99, −0.19) | −0.10 (−0.36, 0.17) | −0.17 (−0.50, 0.15) | −0.09 (−0.83, 0.64) | 0.09 (−0.14, 0.33) | ARB |
0.30 (0.06, 0.55)
n1 = 12/n2 = 910 |
0.50 (−0.03, 1.02) n1 = 1/n2 = 29 | NA | NA | NA | NA | −0.34 (−1.09, 0.41) n1 = 1/n2 = 39 | −1.06 (−2.49, 0.36) n1 = 3/n2 = 435 | NA | NA |
| −0.30 (−0.69, 0.10) | 0.20 (−0.09, 0.48) | 0.12 (−0.20, 0.44) | 0.20 (−0.52, 0.92 | 0.39 (0.14, 0.63) | 0.29 (0.06, 0.53) | CCB | NA | NA | NA | NA | NA | −0.33 (−0.68, 0.01) n1 = 1/n2 = 144 | NA | NA | NA |
| −0.46 (−1.11, 0.19) | 0.03 (−0.52, 0.59) | −0.04 (−0.65, 0.57) | 0.04 (−0.87, 0.94) | 0.22 (−0.32, 0.77) | 0.13 (−0.42, 0.68) | −0.16 (−0.74, 0.41) | RI | NA | NA | NA | NA | NA | NA | NA | NA |
| −0.28 (−1.35, 0.78) | 0.21 (−0.82, 1.24) | 0.13 (−0.92, 1.18) | 0.21 (−1.03, 1.45) | 0.40 (−0.60, 1.40) | 0.31 (−0.72, 1.33) | 0.01 (−1.01, 1.04) | 0.18 (−0.96, 1.31) | AARA | NA | NA | NA | NA | NA | NA | NA |
| −0.96 (−2.03, 0.11) | −0.47 (−1.45, 0.51) | −0.55 (−1.59, 0.50) | −0.47 (−1.70, 0.77) | −0.28 (−1.30, 0.74) | −0.37 (−1.39, 0.65) | −0.67 (−1.69, 0.36) | −0.50 (−1.63, 0.63) | −0.68 (−2.10, 0.75) | DAV | NA | NA | NA | NA | NA | NA |
| −0.52 (−1.58, 0.54) | −0.03 (−1.04, 0.99) | −0.10 (−1.14, 0.93) | −0.02 (−1.25, 1.20) | 0.17 (-0.85, 1.18) | 0.07 (-0.94, 1.08) | −0.22 (−1.22, 0.78) | −0.06 (−1.07, 1.19) | −0.23 (−1.66, 1.19) | 0.44 (−0.97, 1.86) | BB/TD | NA | −0.49 (−1.31, 0.34) n1 = 2/n2 = 124 | NA | NA | NA |
| −0.58 (−1.22, 0.07) | −0.09 (−0.59, 0.42) | −0.16 (−0.77, 0.44) | −0.08 (−0.98, 0.82) | 0.11 (−0.46, 0.67) | 0.01 (−0.55, 0.57) | −0.28 (−0.85, 0.29) | −0.12 (−0.87, 0.63) | −0.29 (−1.44, 0.85) | 0.38 (−0.72, 1.49) | −0.06 (−1.14, 1.02) | TD/ACEI | 0.14 (−0.48, 0.76) n1 = 1/n2 = 40 | NA | 0.35 (−0.07, 0.78) n1 = 3/n2 = 128 | 0.04 (−0.58, 0.66) n1 = 1/n2 = 40 |
| −0.63 (−1.35, 0.08) | −0.23 (−0.96, 0.51) | −0.30 (−1.07, 0.46) | −0.23 (−1.23, 0.78) | −0.04 (−0.77, 0.69) | −0.13 (−0.59, 0.85) | −0.42 (−1.14, 0.29) | −0.26 (−1.15, 0.63) | −0.44 (−1.67, 0.80) | 0.24 (−0.99, 1.47) | −0.20 (−0.90, 0.50) | −0.14 (−0.96, 0.67) | TD/ARB | NA | −0.00 (−0.62, 0.62) n1 = 1/n2 = 40 | −0.27 (−0.54, 0.00) n1 = 1/n2 = 207 |
| −1.35 (−2.10, −0.60) | −0.86 (−1.54, −0.18) | −0.94 (−1.64, −0.23) | −0.86 (−1.83, 0.11) | −0.67 (−1.32, -0.02) | −0.76 (−1.40, −0.13) | −1.06 (−1.73, −0.39) | −0.89 (−1.73, −0.06) | −1.07 (−2.26, 0.12) | −0.39 (−1.59, 0.81) | −0.83 (−2.02, 0.35) | −0.78 (−1.61, 0.06) | −0.63 (−1.59, 0.32) | ACEI/ARB | NA | NA |
| −0.80 (−1.69, 0.09) | −0.31 (−1.11, 0.50) | −0.38 (−1.24, 0.48) | −0.30 (−1.39, 0.78) | −0.12 (−0.95, 0.72) | −0.21 (−1.04, 0.62) | −0.50 (−1.33, 0.33) | −0.34 (−1.31, 0.63) | 0.52 (−1.81, 0.78) | 0.16 (−1.11, 1.43) | −0.28 (−1.41, 0.85) | −0.22 (−0.93, 0.49) | −0.08 (−0.96, 0.80) | 0.55 (−0.48, 1.59) | ACEI/CCB | −0.27 (−0.62, 0.08) n1 = 2/n2 = 128 |
| −0.99 (−1.94, −0.04) | −0.50 (−1.38, 0.39) | −0.57 (−1.50, 0.35) | −0.49 (−1.63, 0.64) | −0.31 (−1.20, 0.59) | −0.40 (−1.29, 0.49) | −0.69 (−1.58, 0.19) | −0.53 (−1.56, 0.50) | −0.71 (−2.05, 0.63) | −0.03 (−1.35, 1.29) | −0.47 (−1.52, 0.58) | −0.41 (−1.28, 0.46) | −0.27 (−1.05, 0.52) | 0.36 (−0.73, 1.45) | −0.19 (−0.91, 0.53) | ARB/CCB |
n1 = trials; n2 = subjects.
AAD: antiadosterone diuretics; AARA: Alpha-adrenergic receptor antagonists; ACEI: Angiotensin-converting enzyme inhibitors; ARB: Angiotensin receptor blockers; BB: beta-blockers; CCB: Calcium channel blockers; TD: thiazide diuretics; DAV: direct-acting vasodilators; PB: placebo; RI: renin inhibitors.