TABLE 4.
Pooled mean differences of different types of antihypertensive drugs on augmentation index including only studies longer than 6 months length. Upper right triangle gives the pooled mean differences from pairwise comparisons (column intervention relative to row), lower left triangle pooled mean differences from the network meta-analysis (row intervention relative to column). * Values p < 0.05 were considered significant.
| PB | NA |
−1.64
(−3.23, −0.06) n1 = 4/n2 = 126 |
NA | NA | NA | NA | NA | NA | NA |
| −0.84 (−2.27, 0.59) |
BB | NA | −0.36 (−0.73, 0.00) n1 = 2/n2 = 338 |
NA | NA |
−0.47
(−0.67, −0.28) n1 = 3/n2 = 602 |
NA | NA | NA |
|
−1.65
(−2.52, -0.78) |
−0.81 (−1.94, 0.32) |
ACEI | 0.39 (−0.19, 0.96) n1 = 5/n2 = 300 |
NA | NA | NA | NA | NA | NA |
|
−1.21
(−2.30, -0.12) |
−0.37 (−1.30, -0.55) |
0.44 (−0.22, 1.10) |
ARB | −0.02 (−0.30, 0.26) n1 = 1/n2 = 200 |
−0.29 (−1.02, 0.44) n1 = 1/n2 = 29 |
NA | NA | NA | NA |
| −1.12 (−2.85, 0.61) |
−0.28 (−1.91, 1.35) |
0.53 (−0.96, 2.02) |
−0.09 (−1.43, 1.25) |
CCB | NA | NA | 0.06 (−0.28, 0.40) n1 = 1/n2 = 131 |
NA | NA |
| −1.51 (−3.35, 0.32) |
−0.77 (−2.41, 1.07) |
0.14 (−1.48,1.76) |
−0.30 (−1.18, 1.78) |
−0.39 (−2.38, 1.60) |
RI | NA | NA | NA | NA |
| −1.21 (−2.92, 0.50) |
−0.37 (−1.31, 0.57) |
0.44 (−1.03,1.91) |
−0.00 (−1.32, 1.32) |
−0.09 (−1.97, 1.79) |
0.30 (−1.68, 2.28) |
TD/ACEI | NA | NA | NA |
| −0.94 (−2.95, 1.06) |
−0.10 (−1.51, 1.31) |
0.71 (−1.10,2.52) |
−0.27 (−1.96, 1.42) |
−0.18 (−2.33, 1.98) |
0.57 (−1.67, 2.81) |
0.27 (−0.79, 1.33) |
TD/ARB | NA | 0.16 (−0.03, 0.34) n1 = 1/n2 = 207 |
| −1.29 (−3.30, 0.73) |
−0.45 (−1.86, 0.97) |
−0.37 (−2.18, 1.45) |
−0.07 (−1.77, 1.62) |
−0.16 (−2.32, 1.99) |
−0.22 (−2.47, 2.02) |
−0.08 (−1.14, 0.99) |
−0.34 (−1.32, 0.63) |
ACEI/CCB | −0.14 (−0.57, 0.30) n1 = 2/n2 = 128 |
| −1.30 (−3.29, 0.69) |
−0.46 (−1.84, 0.93) |
−0.35 (−2.14, 1.4) |
−0.09 (−1.75, 1.58) |
−0.18 (−2.32, 1.96) |
−0.21 (−2.44, 2.01) |
−0.09 (−1.11, 0.93) |
−0.36 (−1.19, 0.48) |
−0.01 (−0.86, 0.84) |
ARB/CCB |
n1 = trials; n2 = subjects.
ACEI: Angiotensin-converting enzyme inhibitors; ARB: Angiotensin receptor blockers; BB: beta-blockers; CCB: Calcium channel blockers; PB: placebo; RI: renin inhibitors; TD: thiazide diuretics.