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. Author manuscript; available in PMC: 2023 Sep 17.
Published in final edited form as: Nat Aging. 2023 Jul 3;3(7):776–790. doi: 10.1038/s43587-023-00446-6

Fig. 1 |. Senescence is a complex cell fate that alters almost every aspect of cell biology.

Fig. 1 |

Some changes observed during senescence involve (1) alterations in protein and glycan receptors, (2) a pro-inflammatory SASP, (3) multiple nuclear abnormalities, such as DNA damage, telomere dysfunction, chromatin alterations and modifications to the nuclear envelope, (4) mitochondrial dysfunction and (5) changes in lysosomal mass and functionality. MMP, matrix metalloproteinase; ROS, reactive oxygen species.