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. Author manuscript; available in PMC: 2023 Sep 17.
Published in final edited form as: Nat Aging. 2023 Jul 3;3(7):776–790. doi: 10.1038/s43587-023-00446-6

Fig. 2 |. Senescence communicates with neighboring cells and alters their function via the SASP.

Fig. 2 |

Senescent cells can (1) spread senescence to surrounding cells, (2) disrupt stem cell niches and thereby impair tissue regeneration, (3) lead to extracellular matrix (ECM) degeneration, resulting in aberrant tissue architecture, (4) drive the recruitment of immune cells and exacerbate tissue inflammation, (5) affect tissue fibrosis and (6) stimulate the proliferation of precancerous cells.