Table 2. MENQoL and Cervantes Scales scores (global and by domains) throughout the study Data are presented as mean ± SD.
| Scales and domains | Baseline | 4 wk | 12 wk | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Score | Score | Reduction (%) | P valuea | Score | Reduction (%) | P valueb | P valuec | ||
| MENQoL | |||||||||
| Vasomotor | 7.2 ± 1.0 | 5.8 ± 0.9 | –19.0 | < 0.001 | 4.2 ± 1.0 | –41.2 | < 0.001 | < 0.001 | |
| Psychosocial | 3.8 ± 1.9 | 3.2 ± 1.5 | –14.5 | < 0.001 | 2.8 ± 1.5 | –26.3 | < 0.001 | < 0.001 | |
| Physical | 4.9 ± 1.6 | 4.3 ± 1.3 | –11.9 | < 0.001 | 3.7 ± 1.4 | –25.0 | < 0.001 | < 0.001 | |
| Sexual | 5.3 ± 1.8 | 4.9 ± 1.5 | –0.3 | 0.0125 | 4.6 ± 1.7 | –7.1 | < 0.001 | < 0.001 | |
| Cervantes scale | |||||||||
| Global | 77.2 ± 26.0 | 63.1 ± 23.5 | –18.6 | < 0.001 | 51.6 ± 26.3 | –35.4 | < 0.001 | < 0.001 | |
| M&H | 46.8 ± 12.9 | 37.5 ± 11.8 | –20.5 | 0.001 | 29.4 ± 14.9 | –39.3 | < 0.001 | < 0.001 | |
| Vasomotor | 14.1 ± 1.6 | 11.0 ± 1.7 | –22.0 | < 0.001 | 7.3 ± 3.1 | –47.3 | < 0.001 | < 0.001 | |
| Health | 15.0 ± 6.0 | 11.4 ± 4.8 | –22.9 | < 0.001 | 9.1 ± 5.3 | –39.3 | < 0.001 | < 0.001 | |
| Aging | 17.7 ± 7.3 | 15.1 ± 7.5 | –16.7 | < 0.001 | 13.0 ± 8.1 | –30.1 | < 0.001 | < 0.001 | |
| Psychic | 16.4 ± 10.0 | 12.6 ± 8.1 | –20.2 | < 0.001 | 9.4 ± 7.7 | –51.7 | < 0.001 | < 0.001 | |
| Sexuality | 11.0 ± 4.9 | 10.9 ± 4.9 | –1.0 | 0.279 | 10.6 ± 4.8 | –4.0 | 0.203 | 0.616 | |
| Couple relationship | 2.9 ± 4.1 | 2.2 ± 3.8 | –24.6 | 0.0009 | 2.3 (4.0) | –15.1 | 0.012 | 0.951 | |
Reduction (%) reflects relative difference vs. basal at a given timepoint.
MENQoL: Menopause-Specific QoL Questionnaire, M&H: menopause & health.
Student’s t test or Wilcoxon sign-ranked test: aweek 4 vs. baseline; bweek 12 vs. baseline; cweek 12 vs. week 4.