Table 3. Total and by-intensity weekly hot flashes throughout the study.

Type of HFs	Baseline		4 wk			12 wk
	Number	Number	Reduction (%)	P valuea	Number	Reduction (%)	P valueb	P valuec
Total	65.3 ± 19.9	43.2 ± 29.7	–32.7	< 0.001	25.7 ± 27.2	–60.0	< 0.001	< 0.001
Mild	9.7 ± 13.6	10.6 ± 13.4	+33.4	0.817	12.3 ± 16.7	+26.0	0.761	0.557
Moderate	31.7 ± 16.5	19.7 ± 14.2	–38.3	< 0.001	8.0 ± 7.8	–72.9	< 0.001	< 0.001
Severe	23.9 ± 10.1	12.9 ± 10.7	–38.0	< 0.001	5.5 ± 9.6	–73.8	< 0.001	< 0.001
Moderate + severe	55.6 ± 15.5	32.7 ± 21.1	–41.7	< 0.001	13.5 ± 15.8	–76.5	< 0.001	< 0.001

Data are presented as mean ± SD.

Mean reduction (%) reflects relative difference vs. basal at a given timepoint.

HFs: hot flashes.

Student’s t test or Wilcoxon sign-ranked test: ^aweek 4 vs. baseline; ^bweek 12 vs. baseline; ^cweek 12 vs. week 4.