Table 1.
Patient characteristics
| Nonmetastatic PPGL (n = 182) | Metastatic PPGL (n = 103) | |
|---|---|---|
| Age at surgery | ||
| Median (range) | 51.0 (12-83) | 48.6 (9-77) |
| Gender | ||
| Female (%) | 95 (52.2%) | 40 (38.8%) |
| Male (%) | 87 (47.8%) | 63 (61.2%) |
| BMIa | ||
| Median (range) | 24.1 (16.7-44.3) | 23.8 (19.9-43.3) |
| Diabetesa | ||
| Yes | 37 (20.3%) | 12 (11.7%) |
| No | 92 (50.5%) | 45 (43.7%) |
| Unknown | 53 (29.1%) | 46 (44.7%) |
| Hypertensiona | ||
| Yes | 122 (67.0%) | 30 (29.1%) |
| No | 29 (15.9%) | 23 (22.3%) |
| Unknown | 31 (17.0%) | 50 (48.5%) |
| Sequencing performed | ||
| Germline | 25 (13.7%) | 80 (77.6%) |
| Somatic | 19 (10.4%) | 2 (1.9%) |
| Germline and somatic | 80 (44.0%) | 5 (4.9%) |
| None | 58 (31.9%) | 16 (15.5%) |
| Mutation status | ||
| Germline | 33 (26.6%) | 46 (52.9%) |
| Somatic | 39 (31.5%) | 4 (4.6%) |
| No mutation | 34 (27.4%) | 3 (3.4%) |
| No mutation by germline (no somatic sequencing) | 18 (14.5%) | 34 (39.1%) |
| Tumor location | ||
| Pheochromocytoma | 156 (85.7%) | 55 (53.4%) |
| Paraganglioma | 25 (13.7%) | 48 (46.6%) |
| Not available | 1 (0.5%) | 0 |
| Tumor size | ||
| Maximal diameter, mean (±SD) in mm | 44.5 (23.2) | 64.7 (37.1) |
Before primary resection of the tumor.
Abbreviations: BMI, body mass index; PPGL, pheochromocytoma and paraganglioma.