Table 3.
List of adipokines and inflammation markers and its observed association with bone mineral density in the type 2 diabetes mellitus population
| Adipokine | BMD | T2DM population | Reference |
|---|---|---|---|
| Leptin | + | Men (N = 28) and women (N = 12) | Tamura et al, 2007 (135) |
| 2-y postbariatric surgery patients (N = 54) | Maghrabi et al, 2015 (136) | ||
| Men (N = 168) | Vasilkova et al, 2011 (137) | ||
| — | Men (N = 93) and women (N = 89) | Kurajoh et al, 2019 (138) | |
|
Adiponectin
Total and/or HMW |
- | Men (N = 42) and women (N = 38) | Lenchik et al, 2003 (139) |
| Men (N = 231) | Kanazawa et al, 2009 (140) | ||
| Men (N = 207) and women (N = 272) | Register et al, 2013 (141) | ||
| With osteoporosis (N = 80) | Chen et al, 2017 (142) | ||
| Women with osteoporosis (N = 90) | Al-Osami and Hameed 2018 (143) | ||
| + | Men (N = 32) (total only) | Kanazawa et al, 2010 (144) | |
| RBP4 | + | Men (N = 109) and women (N = 165) | Huang et al, 2018 (145) |
| TNFα and IL-6 | — | With osteoporosis and diabetic nephropathy (N = 76) | Zhao 2018 (124) |
(+) denotes positive association; (−) denotes inverse association.
Abbreviations: BMD, bone mineral density; HMW, high-molecular-weight; IL-6, interleukin-6; RBP4, retinol-binding protein 4; T2DM, type 2 diabetes mellitus; TNFα, tumor necrosis factor α.