表 1.
两组COVID-19相关ARDS重症患者在进行倾向性得分匹配前的临床特征
Clinical characteristics between two groups in critically ill patients with COVID-19 before propensity score matching
| Items | Total(n=199) | Control group (n=164) | Sivelestat group(n=35) | P |
| MAP: Mean arterial pressure; SCr: Serum creatinine; ALT: Alanine aminotransferase; CRP: C-reactive protein; PCT: Procalcitonin; IL-6: Interleukin- 6; NT- proBNP: N- terminal pro-B- type natriuretic peptide; CRRT: Continuous renal replacement therapy; ECMO: Extracorporeal membrane oxygenation. aThe worst values within the first 24 h after ICU admission were recorded; bThe values on ICU discharge were recorded. | ||||
| Using daysb | 6.00[4.50, 8.50] | |||
| Age (years)b | 70.0 [53.5, 79.0] | 70.0 [53.0, 80.0] | 69 [59.0, 78.0] | 0.649 |
| Gender [n (%)]b | 0.755 | |||
| Male | 138(69.3) | 115(70.1) | 23(65.7) | |
| Female | 61(30.7) | 49(29.9) | 12(34.3) | |
| Comorbidities [n (%)]b | ||||
| Hypertension | 108(58.1) | 91(60.3) | 17(48.6) | 0.283 |
| Diabetes | 79(42.5) | 67(44.4) | 12(34.3) | 0.369 |
| Congestive heart failure | 64(34.4) | 53(35.1) | 11(31.4) | 0.83 |
| Chronic Pulmonary disease | 35(18.8) | 30(19.9) | 5(14.3) | 0.602 |
| Chronic renal disease | 50(26.9) | 39(25.8) | 11(31.4) | 0.644 |
| Liver disease | 31(16.7) | 23(15.2) | 8(22.9) | 0.401 |
| Cerebrovascular disease | 34(18.4) | 25(16.7) | 9(25.7) | 0.316 |
| Tumor | 36(19.4) | 31(20.5) | 5(14.3) | 0.545 |
| APACHE IIa | 24.0 [18.0, 30.0] | 23.0 [17.0, 30.0] | 24.0 [19.5, 30.0] | 0.496 |
| Medication [n (%)]b | ||||
| Paxlovid | 94(50.8) | 77(51.3) | 17(48.6) | 0.915 |
| Ambavirumab | 40(21.6) | 34(22.7) | 6(17.1) | 0.626 |
| Romesimab | 39(21.1) | 33(22) | 6(17.1) | 0.686 |
| Vital sign and Laboratory valuesa | ||||
| Heart rate (min) | 93.7 [82.1, 107.8] | 94.0 [82.5, 105.2] | 90.0 [80.2, 113.0] | 0.935 |
| MAP (mmHg) | 88.5 [76.7, 101.0] | 89.0 [79.0, 101.7] | 83 [68.2, 95.5] | 0.083 |
| Respiratory rate (min) | 12.0 [10.0, 14.0] | 12.0 [10.0, 14.0] | 13 [10.5, 15.0] | 0.059 |
| SPpO2 | 88.0 [80.0, 94.0] | 89.0 [80.0, 95.0] | 87 [79.5, 91.0] | 0.222 |
| PaO2 (mmHg) | 88.5 [68.0, 125.0] | 90.9 [68.9, 127.7] | 78.9 [66.6, 104.5] | 0.159 |
| PaCO2 (mmHg) | 37.7 [33.0, 43.7] | 37.6 [32.8, 43.2] | 39 [33.2, 45.6] | 0.569 |
| PaO2/FiO2 | 179 [111, 285] | 193 [112, 307] | 132 [101, 189] | 0.033 |
| Lactate (mmol/L) | 1.5 [1.0, 2.5] | 1.5 [1.0, 2.5] | 1.4 [1.0, 2.5] | 0.832 |
| White blood cell (×109/L) | 9.40 [6.4, 14.2] | 9.7 [6.6, 14.0] | 8.4 [5.9, 14.6] | 0.297 |
| Hemoglobin (g/dL) | 95.0 [74.5, 120.0] | 94.0 [71.0, 120.0] | 106 [87.0, 120.0] | 0.082 |
| Platelets (×109/L) | 153.0 [106.5, 219.0] | 153.0 [102.0, 219.0] | 152.0 [128.2, 215.2] | 0.351 |
| SCr (mg/dL) | 141.0 [74.0, 296.50] | 146.5 [74.0, 293.0] | 98.0 [76.0, 412.0] | 0.506 |
| ALT(U/L) | 35.0 [23.5, 74.0] | 34.00 [22.0, 67.00] | 54.00 [33.00, 90.00] | 0.058 |
| Albumin (g/L) | 31.9 [27.98, 34.62] | 32.2 [27.6, 34.8] | 31.1 [28.6, 34.1] | 0.45 |
| CRP (mg/L) | 97.2 [41.8, 165.3] | 95.27 [31.6, 161.8] | 132.9 [72.8, 193.1] | 0.116 |
| PCT (μg/L) | 1.8 [1.3, 2.4] | 1.80 [1.30, 2.52] | 1.75 [1.33, 2.28] | 0.537 |
| IL-6 (pg/mL) | 76.4 [22.7, 319.0] | 69.1 [20.5, 301.2] | 145[54.3, 476.0] | 0.09 |
| NT-proBNP (pg/mL) | 2379 [658, 9777] | 2205 [632, 9487] | 3927 [1198, 10783] | 0.128 |
| Fluid balanceb | ||||
| Output (mL) | 6356 [4603, 8436] | 6374 [4602, 8412] | 6356 [4788, 9312] | 0.582 |
| Intput (mL) | 8358 [6373, 10368] | 8320 [6361, 10162] | 8816 [6460, 11635] | 0.417 |
| Volume (mL) | 1470 [-113, 3718] | 1420 [-92, 3739] | 1521 [-179, 3661] | 0.81 |
| Mechanical ventilation [n (%)] | 138(75.0) | 104(69.3) | 34(100.0) | < 0.001 |
| Treatmentb | ||||
| Prone ventilation [n (%)] | 44(25.4) | 30(21.6) | 14(41.2) | 0.033 |
| Vasopressor use [n (%)] | 135(84.4) | 103(81.7) | 32(94.1) | 0.134 |
| CRRT [n (%)] | 86(47.5) | 65(44.2) | 21(61.8) | 0.098 |
| ECMO [n (%)] | 9(4.9) | 5(3.4) | 4(11.8) | 0.111 |
| Transitions | ||||
| Hospitalization [n (%)] | 36(18.1) | 35(21.3) | 1(2.9) | |
| Discharge [n (%)] | 67(33.7) | 53(32.3) | 14(40.0) | |
| Death [n (%)] | 96(48.2) | 76(46.3) | 20(57.1) | |