表 2.
两组COVID-19相关ARDS重症患者在进行倾向性得分匹配后的临床特征
Clinical characteristics between two groups in critically ill patients with COVID-19 after propensity score matching
| Items | Total (n=105) | Control group (n=70) | Sivelestat group (n=35) | P |
| APACHE: Acute physiologic and chronic health evaluation; MAP: Mean arterial pressure; SCr: Serum creatinine; ALT: Alanine aminotransferase; CRP: C-reactive protein; PCT: Procalcitonin; IL-6: Interleukin-6; NT-proBNP: N-terminal pro-B-type natriuretic peptide; CRRT: Continuous renal replacement therapy; ECMO: Extracorporeal membrane oxygenation. aThe worst values within the first 24 h after ICU admission were recorded; bThe values on ICU discharge were recorded. | ||||
| Using daysb | 6.00 [4.50, 8.50] | |||
| Age (years) | 71.0 [59.0, 79.0] | 71.0 [59.2, 79.7] | 69.0 [59.0, 78.0] | |
| Gender [n (%)] | ||||
| Male | 69 (65.7) | 46 (65.7) | 23 (65.7) | 0.9 |
| Female | 36 (34.3) | 24 (34.3) | 12 (34.3) | 1 |
| Co-morbidities [n (%)] | ||||
| Hypertension | 64 (61.0) | 47 (67.1) | 17 (48.6) | 0.104 |
| Diabetes | 41 (39.0) | 29 (41.4) | 12 (34.3) | 0.621 |
| Congestive heart failure | 33 (31.4) | 22 (31.4) | 11 (31.4) | 1 |
| Chronic Pulmonary disease | 17 (16.2) | 12 (17.1) | 5 (14.3) | 0.925 |
| Chronic renal disease | 28 (26.7) | 17 (24.3) | 11 (31.4) | 0.585 |
| Liver disease | 18 (17.1) | 10 (14.3) | 8 (22.9) | 0.41 |
| Cerebrovascular disease | 24 (22.9) | 15 (21.4) | 9 (25.7) | 0.805 |
| Tumor | 27 (25.7) | 22 (31.4) | 5 (14.3) | 0.097 |
| APACHE II | 24.0 [18.0, 30.0] | 24.0 [18.0, 30.7] | 24.0 [19.5, 30.0] | 0.962 |
| Medication [n (%)]b | ||||
| Paxlovid | 58 (55.2) | 41 (58.6) | 17 (48.6) | 0.445 |
| Ambavirumab | 28 (26.7) | 22 (31.4) | 6 (17.1) | 0.185 |
| Romesimab | 28 (26.7) | 22 (31.4) | 6 (17.1) | 0.185 |
| Vital sign and Laboratory valuesa | ||||
| Heart rate (min) | 94.0 [85.0, 111.0] | 96.0 [86.5, 105.0] | 90.0 [80.5, 113.0] | 0.591 |
| MAP (mmHg) | 87.0 [74.0, 100.0] | 87.5 [78.2, 100.7] | 83.0 [68.5, 96.0] | 0.205 |
| Respiratory rate (min) | 12.0 [10.0, 14.0] | 12.0 [10.0, 13.0] | 13.0 [10.5, 15.0] | 0.19 |
| SPO2 | 86.0 [79.0, 92.00] | 85.5 [78.2, 92.7] | 87.0 [79.5, 91.0] | 0.76 |
| PaO2 (mmHg) | 79.0 [67.1, 103.0] | 80.2 [67.4, 101.7] | 78.9 [66.6, 104.5] | 0.903 |
| PaCO2 (mmHg) | 38.5 [33.2, 44.3] | 38.2 [33.2, 43.4] | 39.0 [33.2, 45.6] | 0.698 |
| PaO2/FiO2 ratio | 132 [97, 213] | 136 [97, 236] | 132 [101, 189] | 0.881 |
| Lactate (mmol/L) | 1.5 [1.1, 2.7] | 1.6 [1.1, 2.6] | 1.40 [1.0, 2.4] | 0.596 |
| White blood cell (×109/L) | 9.3 [6.2, 14.6] | 10.1 [6.2, 14.5] | 8.3 [5.7, 14.5] | 0.318 |
| Hemoglobin (g/dl) | 97.0 [75.0, 120.0] | 96.0 [73.0, 119.7] | 105.0 [84.0, 119.0] | 0.193 |
| Platelets (×109/L) | 138.0[105.0, 199.0] | 127.0 [73.5, 191.0] | 158.0[128.5, 222.5] | 0.14 |
| SCr (mg/dl) | 121.0 [74.0, 287.0] | 129.0 [74.0, 267.0] | 98.0 [76.0, 378.5] | 0.698 |
| ALT (U/L) | 45.0 [28.0, 83.0] | 39.5 [26.0, 76.5] | 56.0 [33.0, 90.5] | 0.253 |
| Albumin (g/L) | 31.7 [27.6, 34.2] | 31.8 [27.3, 34.2] | 31.0 [28.3, 33.6] | 0.757 |
| CRP (mg/L) | 108.8 [63.8, 181.9] | 107.1 [62.2, 180.2] | 130.3 [67.8, 189.4] | 0.823 |
| PCT (μg/L) | 1.7 [1.3, 2.3] | 1.70 [1.30, 2.28] | 1.80 [1.30, 2.25] | 0.93 |
| IL-6 (pg/mL) | 115.0 [44.6, 362.0] | 110.0 [37.9, 356.5] | 145.0 [52.4, 411.5] | 0.584 |
| NT-proBNP (pg/mL) | 2417 [836, 11796] | 2096 [761, 11376] | 3927 [1167, 11649] | 0.296 |
| Fluid balanceb | ||||
| Output (mL) | 6358 [4493, 8413] | 6479 [4431, 8384] | 6358 [4822, 9149] | 0.503 |
| Intput (mL) | 8758 [6908, 11067] | 8739 [7163, 10445] | 8994 [651, 11538] | 0.962 |
| Volume (mL) | 2189 [63, 4163] | 2419 [81, 4386] | 1748 [-139, 3661] | 0.384 |
| Treatmentb | ||||
| Mechanical Ventilation [n (%)] | 102 (97.1) | 68 (97.1) | 34 (97.1) | 1 |
| Prone ventilation [n (%)] | 34 (32.4) | 20 (28.6) | 14 (40.0) | 0.338 |
| Vasopressor use [n (%)] | 97 (92.4) | 65 (92.9) | 32 (91.4) | 1 |
| CRRT [n (%)] | 55 (52.4) | 34 (48.6) | 21 (60.0) | 0.369 |
| ECMO [n (%)] | 8 (7.6) | 4 (5.7) | 4 (11.4) | 0.516 |
| Transitions | ||||
| Hospitalization [n (%)] | 13 (12.4) | 12 (17.1) | 1 (2.9) | |
| Discharge [n (%)] | 29 (27.6) | 15 (21.4) | 14 (40.0) | |
| Death [n (%)] | 63 (60.0) | 43 (61.4) | 20 (57.1) | |