. 2023 Aug 20;43(8):1279–1286. [Article in Chinese] doi: 10.12122/j.issn.1673-4254.2023.08.03

表 2.

小鼠体内有限稀释实验检测二甲双胍对结直肠癌干细胞成瘤能力的影响

Limiting dilution assays on tumor-initiating frequencies (TIFs) of metformin-treated colorectal CSCs in vivo

No.	Gender	Age (year)	TNM stage	Group	Cell doses			TIFs (95% CI)	P
No.	Gender	Age (year)	TNM stage	Group	10⁴	10³	10²	TIFs (95% CI)	P
TIFs: Tumor initiating frequencies.
PDO1	Male	48	T3N2M0	Control	8/10	5/10	3/10	1/3110 (1/1551-1/6402)	< 0.001
PDO1	Male	48	T3N2M0	Metformin	3/10	1/10	0/10	1/23611 (1/8705-1/64038)	< 0.001
PDO2	Female	89	T4aN0M0	Control	10/10	8/10	4/10	1/453 (1/227-1/905)	< 0.001
PDO2	Female	89	T4aN0M0	Metformin	6/10	4/10	2/10	1/5896 (1/2972-1/11696)	< 0.001
PDO3	Female	59	T4aN1M0	Control	10/10	7/10	4/10	1/576 (1/289-1/1149)	< 0.001
PDO3	Female	59	T4aN1M0	Metformin	8/10	3/10	0/10	1/5218 (1/2639-1/10318)	< 0.001