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. 2023 Jul 27;202(2):367–375. doi: 10.1007/s10549-023-07059-y

Table 2.

Patient and tumor characteristics for ER and PR status independently. Data expressed as n (%) unless otherwise specified

ER Low n = 78 ER Intermediate n = 107 ER High
n = 522
P value PR Low
n = 229
PR High
n = 478
P value
Age (years) 56.6 56.7 60.6 0.0006 63.6 57.6  < 0.0001
BMI
 18.5–24 52.4 54.3 51.0 0.107 50.0 52.4 0.763
25–29 30.2 35.1 26.8 30.2 27.5
≥30 17.5 10.6 22.2 19.8 20.1
Overall stage
 1 52 (67.5) 69 (65.1) 315 (62.1) 0.514 137 (62.3) 299 63.6) 0.018
 2 20 (26.0) 23 (21.7) 125 (24.7) 45 (20.5) 123 (26.2)
 3 5 (6.5) 14 (13.2) 67 (13.2) 38 (17.3) 48 (10.2)
Tumor grade
 1 32 (41.6) 31 (29.8) 126 (24.5) 0.03 59 (26.6) 130 (27.5) 0.113
 2 41 (53.3) 69 (66.4) 363 (70.6) 147 (66.2) 326 (68.9)
 3 4 (5.2) 4 (3.9) 25 (4.9) 16 (7.2) 17 (3.6)
Receptor subtype
 ER + PR + HER2- 47 (8.2) 77 (13.5) 448 (78.3)  < 0.001 126 (22.0) 446 (78.0)  < 0.001
 ER + PR-HER2- 16 (21.1) 14 (18.4) 46 (60.5) 76 (100.0) 0 (0.0)
 HER2 +  7 (22.6) 9 (29.1) 15 (48.4) 16 (51.6) 15 (48.4)
High Ki67 (> 14%) 6 (33.3) 16 (42.1) 117 (38.7) 0.818 47 (32.9) 96 (67.1) 0.615
Presence of LVI 6 (8.1) 8 (7.8) 24 (4.7) 0.282 17 (7.8) 21 (4.5) 0.080
Presence of LCIS 50 (65.8) 66 (63.5) 371 (72.8) 0.104 137 (62.6) 350 (74.3) 0.002
Type of treatment
 Lumpectomy 14 (17.9) 20 (18.7) 86 (16.8) 0.790 50 (22.4) 70 (14.7) 0.044
 Lumpectomy + rad 21 (26.9) 35 (32.7) 183 (35.7) 69 (30.9) 170 (35.8)
 Mastectomy 30 (38.5) 35 (32.7) 176 (34.3) 69 (30.9) 172 (36.2)
 Mastectomy + rad 13 (16.7) 17 (15.9) 68 (13.3) 35 (15.7) 63 (13.3)
Neoadj chemotherapy 19 (24.7) 18 (18.9) 48 (10.5) 0.001 36 (17.4) 49 (11.6) 0.048
Adj chemotherapy 51(65.8) 83 (77.1) 425 (81.4) 0.007 63 (28.4) 108 (22.9) 0.117

N(%)

BMI body mass index; ER Estrogen receptor; PR progesterone receptor; LVI lymphovascular invasion; LCIS lobular carcinoma in situ; HER2 Human Epithelial Growth Factor Receptor-2; ILC invasive lobular carcinoma; Neg negative; Rad radiation; Neoadj neoadjuvant; Adj adjuvant