Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Sep 1;14:1260973. doi: 10.3389/fimmu.2023.1260973

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2023 Alberro-Brage, Kryvenko, Malainou, Günther, Morty, Seeger, Herold, Samakovlis and Vadász

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Megalin is downregulated in AEC from IV-infected mice. (A–F) Lung samples were obtained from mice 5 days after intratrachaeal instillation of 350 pfu of IV (n=5). (A) Whole protein contents from the BAL fluid of control (Mock) and infected (IV) mice. (B) AEC from lung samples were analyzed by FC for viral proteins (HA). Graph shows percentages for HA+ cells in mock (M) and infected (IV) samples. (C) TGF-β1 levels were measured in the BALF from control and IV-infected mice following 3, 4, 5, 7, 8 and 9 days of infection by ELISA. (D, E) AEC were isolated and analyzed by western blot. (D) Top: Densitometric quantification of p-GSK3β. Bottom: Representative blot. (E) Top: Densitometric quantification of megalin. Bottom: Representative blot. *p<0.05.