Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Sep 1;14:1260973. doi: 10.3389/fimmu.2023.1260973

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2023 Alberro-Brage, Kryvenko, Malainou, Günther, Morty, Seeger, Herold, Samakovlis and Vadász

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

IV infection alters MMP expression levels in AEC and BAL fluid cells.(A, B) mRNA levels of the top 6 most expressed MMP and Timp2 in AEC (A) and BAL (B) from infected mice. Normalized RNAseq data, n=3. Bars represent mean ± SD. TPM: transcripts per million. (C, D) MLE-12 cells (C) or PCLS (D) were inoculated with IV for 24 h and the protein extracts analyzed by western blot. Representative blots and MMP/actin densitometry ratio graphs are shown. Values represent mean ± SD, n=3. (C) In MLE-12 cells protein expression of MMP-12 was upregulated in IV conditions, while expression of MMP-2, MMP-14 and MMP-19 did not show significant differences. Representative megalin and actin immunoblots are shown. (D) In PCLS, protein expression of MMP-9 was downregulated, while no significant differences were found in MMP-2 and MMP-14 expression. *p<0.05; ***p<0.005.