Table 3.
Association of MACE with CPET parameter. Shown are estimates and 95% CI for MACE from the mixed linear models with the respective CPET parameter as the dependent variable and covariates age and sex, and with site as random factor. Models were performed for patients with and without LVD and for the total population to test for group interaction.
| LVD (n = 151, 25 with MACE) | No LVD (n = 667, 104 with MACE) | Interaction MACE × LVD | |||
|---|---|---|---|---|---|
| Beta | 95%CI | Beta | 95%CI | p-value | |
| VO2 peak [ml/kg/min] | −1.150 | −2.842, 0.520 | −1.249 | −2.136, −0.354 | 0.7608 |
| VE/VCO2 slope | 3.448 | −0.092, 7.046 | 2.244 | 0.757, 3.739 | 0.3159 |
| Nadir VE/VCO2 | 2.843 | 0.071, 5.615 | 1.189 | 0.091, 2.294 | 0.1022 |
| PETCO2 resting [mmHg] | −0.951 | −2.573, 0.653 | −0.250 | −1.093, 0.593 | 0.3158 |
| PETCO2 peak [mmHg] | −1.880 | −3.759, −0.019 | −0.404 | −1.328, 0.515 | 0.0860 |
| VE resting [L/min] | 0.882 | −0.853, 2.632 | −0.795 | −1.613, 0.027 | 0.0742 |
| VE peak [L/min] | 2.644 | −3.855, 9.105 | −2.302 | −5.390, 0.803 | 0.3411 |
| BF resting [min−1] | 2.985 | 0.639, 5.418 | −0.688 | −2.097, 0.714 | 0.0086 |
| BF peak [min−1] | 2.928 | −0.265, 6.122 | 1.200 | −0.506, 2.888 | 0.5638 |
| VT resting [L] | −0.055 | −0.165, 0.054 | −0.018 | −0.073, 0.038 | 0.4746 |
| VT peak [L] | −0.155 | −0.334, 0.021 | −0.075 | −0.173, 0.023 | 0.2658 |
LVD, left ventricular dysfunction; MACE, major adverse cardiac event: VO2, oxygen uptake; VE/VCO2, ventilation/carbon dioxide production; PETCO2, endtidal carbon dioxide partial pressure; BF, breathing frequency; VT, tidal volume.