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. 2023 Aug 31;14:1239398. doi: 10.3389/fendo.2023.1239398

Table 2.

Logistic regression analyses for the association between ALT/HDL-C ratio, AST/HDL-C ratio, GGT/HDL-C ratio and NAFLD.

Odds ratios (95% confidence interval)
Unadjusted model Model 1 Model 2 Model 3
ALT/HDL-C ratio (Per SD increase) 8.61 (7.80, 9.51) 3.30 (2.96, 3.67) 3.23 (2.90, 3.60) 3.05 (2.63, 3.53)
AST/HDL-C ratio (Per SD increase) 5.47 (4.99, 6.00) 2.02 (1.82, 2.23) 1.96 (1.77, 2.17) 1.45 (1.30, 1.62)
GGT/HDL-C ratio (Per SD increase) 2.41 (2.29, 2.53) 1.38 (1.31, 1.45) 1.43 (1.35, 1.50) 1.20 (1.14, 1.27)
ALT/HDL-C ratio (Quartile)
Quartile 1 Ref Ref Ref Ref
Quartile 2 3.05 (2.26, 4.12) 2.01 (1.47, 2.75) 1.99 (1.46, 2.73) 1.83 (1.34, 2.51)
Quartile 3 10.71 (8.15, 14.07) 4.39 (3.27, 5.89) 4.32 (3.22, 5.80) 3.68 (2.73, 4.96)
Quartile 4 55.53 (42.58, 72.42) 14.60 (10.87, 19.61) 14.34 (10.66, 19.28) 9.96 (7.32, 13.57)
P-trend <0.0001 <0.0001 <0.0001 <0.0001

ALT/HDL-C ratio: alanine aminotransferase to high-density lipoprotein cholesterol ratio; SD: standard deviation; NAFLD: non-alcoholic fatty liver disease.

Model 1 adjusted for age, sex, height and BMI;

Model 2 adjusted for age, sex, height, BMI, exercise habits, smoking status and drinking status;

Model 3 adjusted for age, sex, height, BMI, exercise habits, smoking status, drinking status, AST, GGT, TC, TG, FPG, HbA1c and SBP.

In the analysis of AST/HDL-C ratio and GGT/HDL-C ratio and NAFLD in Model 3, the variables themselves were not adjusted.