Table 3.
Combination of ADH1B rs1229984, ADH1C rs698and ALDH2 rs671 Genotypes in Sample Groups
| Genotype | Likely phenotype | Healthy non-alcoholics | Alcoholics N=206 (2) | 1/2 (%) | P values, OR | Non-ALC N=100 (3) | ALC N=106 (4) | 3/4 (%) | P values, OR | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| ADH1B (rs1229984) | ADH1C (rs698) | ALDH2 (rs671) | |||||||||
| *1/*1 | *1/*1 | *1/*1 | Increasing risk for alcoholism/non-acetaldehyde accumulation | 5 | 14 | 8/12.62 | 0.228 | 5 | 10 | 8/16.98 | 0.035, 2.51 (1.05-6.03) |
| *1/*1 | *1/*2 | *1/*1 | 3 | 10 | 3 | 7 | |||||
| *1/*1 | *2/*2 | *1/*1 | 0 | 2 | 0 | 2 | |||||
| *1/*1 | *1/*1 | *1/*2 | Reducing the risk for alcoholism/low acetaldehyde accumulation | 0 | 3 | 58/67.96 | 0.087 | 2 | 1 | 65/70.75 | 0.461 |
| *1/*1 | *1/*2 | *1/*2 | 2 | 0 | 0 | 0 | |||||
| *1/*2 | *1/*1 | *1/*1 | 17 | 44 | 22 | 22 | |||||
| *1/*2 | *1/*2 | *1/*1 | 9 | 15 | 6 | 9 | |||||
| *2/*2 | *1/*1 | *1/*1 | 26 | 75 | 34 | 40 | |||||
| *2/*2 | *1/*2 | *1/*1 | 4 | 3 | 1 | 2 | |||||
| *1/*2 | *1/*1 | *1/*2 | Reducing the risk for alcoholism/highacetaldehyde accumulation | 11 | 15 | 34/19.42 | 0.005, 0.47 (0.27-0.8) | 9 | 9 | 27/12.26 | 0.008, 0.48 (0.24-0.96) |
| *1/*2 | *1/*1 | *2/*2 | 2 | 2 | 2 | 0 | |||||
| *1/*2 | *1/*2 | *1/*2 | 5 | 8 | 6 | 2 | |||||
| *2/*2 | *1/*1 | *1/*2 | 12 | 12 | 7 | 5 | |||||
| *2/*2 | *1/*1 | *2/*2 | 4 | 1 | 1 | 0 | |||||
| *2/*2 | *1/*2 | *1/*2 | 0 | 1 | 1 | 0 | |||||
| *2/*2 | *1/*2 | *2/*2 | 0 | 1 | 1 | 0 | |||||
Abbreviations: N, number of subjects; SD, standard deviation; OR, odds ratio; CI, confidence interval; P< 0.05 was considered statistically significant; The OR between groups was calculated based on comparing the odd of combined genotype of interest and odd of remaining genotypes. OR values indicate the risk of alcoholics or ALC compared with reference groups while individuals carrying the certain combined genotypes.