Table 5.
Combination of ADH1B rs1229984, ADH1C rs698 and ALDH2 rs671 Genotypes with ALC Status
| Genotype | N | Child-Pugh Score for combined genotype | Likely phenotype |
Likely Phenotype ratio (%) |
Child-Pugh Score for likely phenotype | ||||
|---|---|---|---|---|---|---|---|---|---|
| ADH1B (rs1229984) |
ADH1C
(rs698) |
ALDH2 (rs671) | mean value ± SD | P value | mean value ± SD | P value | |||
| *1/*1 | *1/*1 | *1/*1 | 10 | 8.2 ± 2.390 | 0.499 | Increasing risk for alcoholism /non-acetaldehyde accumulation | 17.93 | 8.32 ± 2.028 | 0.854 |
| *1/*1 | *1/*2 | *1/*1 | 7 | 8.0 ± 1.826 | |||||
| *1/*1 | *2/*2 | *1/*1 | 2 | 10.0 ± 0.0 | |||||
| *1/*1 | *1/*1 | *1/*2 | 1 | 10.0 ± 0.0 | 0.545 | Reducing the risk for alcoholism/low acetaldehyde accumulation | 69.81 | 8.19 ± 2.453 | |
| *1/*2 | *1/*1 | *1/*1 | 22 | 8.14 ± 2.356 | |||||
| *1/*2 | *1/*2 | *1/*1 | 9 | 9.0 ± 3.123 | |||||
| *2/*2 | *1/*1 | *1/*1 | 40 | 8.10 ± 2.437 | |||||
| *2/*2 | *1/*2 | *1/*1 | 2 | 6.0 ± 0.0 | |||||
| *1/*2 | *1/*1 | *1/*2 | 6 | 9.0 ± 2.898 | 0.243 | Reducing the risk for alcoholism/high acetaldehyde accumulation | 12.26 | 7.85 ± 2.178 | |
| *1/*2 | *1/*2 | *1/*2 | 2 | 6.50 ± 0.707 | |||||
| *2/*2 | *1/*1 | *1/*2 | 5 | 7.0 ± 1.00 | |||||
Abbreviations: N, number of subjects; SD, standard deviation; P< 0.05 was considered statistically significant.