Table 1.
Characteristics of the included studies.
| Author | Year | Country | Study Design | Ethnicity | Sample Size | Method | Outcome | Age(Years) | LDH Cut-off | Treatment | NOS |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Shi et al. (14) | 2023 | China | Retrospective | Asian | 174 | UVA/MVA | OS, DFS | 63.4 | 193 | Resection | 7 |
| Yildirim et al. (16) | 2022 | Turkey | Retrospective | Caucasian | 56 | MVA | OS, DFS | 61.23 + 8.89 | ULN | Resection+ Chemotherapy | 7 |
| Chen et al. (15) | 2022 | China | Retrospective | Asian | 146 | UVA/MVA | OS, DFS | 61 | 250 | Immunotherapy | 6 |
| Marshall et al. (19) | 2022 | Japan | Retrospective | Asian | 133 | UVA/MVA | OS | 65 | 222 | Chemotherapy | 7 |
| Hu et al. (18) | 2021 | China | Retrospective | Asian | 61 | UVA/MVA | DFS | 55.61 + 11.97 | 299 | Immunotherapy | 7 |
| Ma et al. (17) | 2021 | China | Retrospective | Asian | 615 | UVA/MVA | OS | 66 | 220 | Resection | 6 |
| Zhou et al. (20) | 2020 | China | Retrospective | Asian | 112 | MVA | OS | 57 | 250 | Chemotherapy | 6 |
| Namikawa et al. (21) | 2019 | Japan | Retrospective | Asian | 262 | MVA | OS | 69 | 222 | Chemotherapy | 4 |
| Fanotto et al. (22) | 2017 | Italy | Retrospective | Caucasian | 868 | UVA/MVA | OS, DFS | 64 | 480 | Chemotherapy | 5 |
| Fuchs et al. (23) | 2017 | Multiple | Retrospective | Mixed | 355 | MVA | OS | 65 | ULN | Chemotherapy | 6 |
| Wang et al. (24) | 2016 | China | Retrospective | Asian | 619 | MVA | OS, DFS | 57.9 | ULN | Resection + Chemotherapy | 6 |
| Sun et al. (26) | 2014 | China | Retrospective | Asian | 264 | UVA/MVA | OS | 59 | ULN | Resection | 6 |
| Turkoz et al. (28) | 2014 | Turkey | Retrospective | Caucasian | 176 | UVA | OS | 57.8 | ULN | Multiple treatment strategies | 7 |
| Wang et al. (25) | 2014 | China | Retrospective | Asian | 439 | MVA | OS | 60 | 245 | None | 3 |
| Zhao et al. (27) | 2014 | China | Retrospective | Asian | 365 | UVA/MVA | OS, DFS | 55 | 245 | Resection | 7 |
| Chung et al. (29) | 2013 | Taiwan | Retrospective | Asian | 53 | UVA | OS | 63.5 | ULN | Resection + Chemotherapy | 7 |
| Lu et al. (30) | 2013 | China | Retrospective | Asian | 319 | MVA | OS | 69 | ULN | Chemotherapy | 4 |
| Sougioultzis et al. (31) | 2011 | Greece | Retrospective | Caucasian | 311 | MVA | OS | 62 | 225 | Chemotherapy | 4 |
UVA, Univariate Analysis; MVA, Multivariate Analysis; OS, Overall Survival; DFS, Disease Free Survival; LDH, Lactate Dehydrogenase; ULN, Upper limit of Normal.