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. 2023 Aug 31;14:1263329. doi: 10.3389/fimmu.2023.1263329

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Copyright © 2023 Zhao, Wang, Ni, Zhang, Liu, Xie, Ji, Cheng and Zhou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BARD1 is a marker of poor prognosis in GBM patients. (A) Three genes common to exosome-related and model genes were obtained by differential analysis in single-cell sequencing. (B) Expression of three genes in the TCGA cohort. (C) Kaplan-Meier survival curves for OS of patients in the high and low BARD1+ malignant cell expression groups. (D) Prediction of response to immunotherapy by TIDE based on the proportion of BARD1+ malignant cells. (E) Correlation between the proportion of BARD1+ malignant cells and CAF cell content. (F) Spatial map of BARD1 expression. (G) Interacting ligand-receptor pairs of top50. (H) Ligand-receptor communication of different cell types in space. (I) The spatial plot of COL4A2-CD93 ligand-receptor pair scores. *** p< 0.001.