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STC-1 reduces IOP in the DBA/2J mouse. (a) Complete experiment displayed in a longitudinal fashion. (b) At experimental days 6–8, STC-1 lowered IOP compared to PBS (n = 10). (c) Representative toluidine blue-stained sections of 14-month old DBA/2J mice treated with PBS in one eye and STC-1 in the fellow eye show angle closure with synechiae formation (asterisk), iris atrophy (arrow), and pigment-laden macrophages (chevron). ***P < .001. Error bars represent mean ± standard deviation.
