Table 2.
Frequencies and proportions of clinical and biological factors, by sCD163 below or above median (3112 ng/mL)
| sCD163 low n = 65, n (%) |
sCD163 high n = 66, n (%) |
P value | ||
|---|---|---|---|---|
| Number of events | Died | 11 (24) | 34 (76) | |
| Relapsed | 21 (33) | 42 (67) | ||
| Time of sample | Diagnosis | 39 (48) | 42 (52) | .8∗ |
| Relapse | 26 (52) | 24 (48) | ||
| Age median (range) | 69 (46-85) | 67 (45-82) | .8† | |
| Sex | Female | 17 (47) | 19 (53) | .7∗ |
| Male | 48 (51) | 47 (49) | ||
| ECOG | 0-1 | 40 (48) | 43 (52) | .2‡ |
| 2-4 | 0 (0) | 3 (100) | ||
| Unknown | 25 | 20 | ||
| MIPI | 1 | 14 (67) | 7 (33) | .2∗ |
| 2 | 27 (52) | 25 (48) | ||
| 3 | 23 (43) | 31 (57) | ||
| Unknown | 1 | 3 | ||
| LDH | Normal | 45 (64) | 25 (36) | <.001∗ |
| High | 19 (33) | 38 (67) | ||
| Unknown | 1 | 3 | ||
| Hb | Normal | 46 (66) | 24 (34) | <.001∗ |
| Low | 15 (28) | 39 (72) | ||
| Unknown | 4 | 3 | ||
| Ki-67 | <30 | 13 (48) | 14 (52) | .7∗ |
| ≥30 | 22 (54) | 19 (46) | ||
| Unknown | 30 | 33 | ||
| Histology | Classic | 28 (54) | 24 (46) | .9∗ |
| Blastoid | 9 (56) | 7 (44) | ||
| Unknown | 28 | 35 | ||
| TP53/p53 | Low or no mutation | 36 (59) | 25 (41) | .015‡ |
| High or mutated | 4 (25) | 25 (75) | ||
| Unknown | 25 | 29 |
High sCD163 was more common in patients with high LDH, low Hb and p53 high/TP53 positive tumors.
ECOG, ECOG performance status scale; LDH, lactate dehydrogenase; MIPI, mantle cell lymphoma international prognostic index.
Data are presented as number (percentage), unless otherwise indicated.
Boldface indicates statistically significant values.
∗
Pearson χ2 test.
†
Wilcoxon rank sum test.
‡
Fisher exact test.