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. 2023 Sep 18;14:60. doi: 10.1186/s13293-023-00544-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — 3D conformation of the TLR7–TLR8 genomic region in male and female cells. A Idiogram of the human X chromosome with the positions of the adjacent genes, TLR7 and TLR8, and three marker genes, CFP, MSN and PGK1, that do not evade X chromosome inactivation. B Map of the TLR7, TLR8-AS1 and TLR8 locus on Xp22.2; tel, cen denote the telomeric and centromeric ends of the map. C Hi-C map of interactions around the TLR7–TLR8 region on the active (Xa, top panel) or inactive (Xi, bottom panel) X chromosome at 5-kb resolution in GM12878 human female cells. D Hi-C map of interactions around the TLR7–TLR8 region at 1-kb resolution in GM12878 human female cells (datasets in C and D from Rao et al. [65]). The dark blue circle denotes a peak of interaction (loop anchor) between TLR7 and PRPS2 as determined by the Peak tool in the Juicebox software. Blue and yellow dashed lines represent domains of preferential interactions as defined by the Contact Domain tool in Juicebox. E, F Hi-C maps of interactions around the TLR7–TLR8 region at 5-kb resolution in human male monocytes E, F, top; dataset from Phanstiel et al., [66]) versus GM12878 human female cells (E, bottom, dataset from Rao et al., [65]) or male T cells (F, bottom panel, dataset from Zhang et al., [67]). Blue dashed lines represent domains of preferential interactions as defined by the Contact Domain tool in Juicebox