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. 2023 Sep 18;24:347. doi: 10.1186/s12859-023-05481-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Predicted LOF-intolerant genes with $\leq 10$ expected LOF variants. a Venn diagram of predicted LOF-intolerant genes. b Enrichment of essential genes in the 109 LOF-intolerant genes uniquely predicted by DeepLOF. Error bars represent 95% confidence intervals. c Proportion of benign genomic deletions overlapping the 109 LOF-intolerant genes uniquely predicted by DeepLOF. The histogram represents the null distribution of the proportion from a permutation test, and the dashed vertical line represents the observed proportion in empirical data