Prognosis assessment after hypoxic ischemic encephalopathy (HIE) should be performed using a standard prognostic algorithm.

If epileptic seizures are clinically or electroencephalographically detectable following an HIE, anticonvulsant therapy should be administered at a sufficiently high dose and for a sufficiently long period of time

Patients with persistent consciousness disorder after HIE, as well as those with a suspected diagnosis of hypoactive delirium, should receive an EEG diagnosis in order not to overlook a potentially treatable non-convulsive status epilepticus.

The therapy of delirium should basically consist of non-medicinal and medicinal components.

Haloperidol can be an option for treatment of hyperactive delirium; there is currently no pharmaceutical therapeutic option for hypoactive delirium.