Fig. 5.

Intra-articular levels of IL6, CCL2, and CTXII at 4 weeks after intra-articular injection of IDO-Gal3 or saline in MCLT + MMT operated knees (Week 12 timepoint). At 4 weeks after intra-articular injection (Week 12 timepoint), joint levels of IL6 were significantly decreased in the IDO-Gal3-treated operated knees compared to saline-treated operated knees (A, p = 0.03). Intra-articular levels of CCL2 (B) and CTXII (C) were not elevated in saline-treated operated knees compared to contralateral controls, and as such, shifts due to IDO-Gal3 treatment could not be detected (p = 0.073 for CCL2 and p = 0.090 for CTXII). Bars represent mean ± 95% confidence interval