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. 2023 Sep 18;23:879. doi: 10.1186/s12885-023-11358-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Screening EMT-related genes used for constructing the risk signature for EC. A The circle shows that these 540 EMT-related genes are differentially expressed between cancer and normal tissues. The inner layer presents the genes expression in cancer tissues, and the outer layer shows the genes expression in normal tissues. B The circle represents 278 EMT-related genes significantly associated with EC survival. C The most appropriate log (Lambda) value in the LASSO model. D The LASSO coefficient profiles of the EMT-related prognostic genes. E Multivariate Cox regression analysis was performed and four EMT-related genes (SIRT2, SIX1, CDKN2A and PGR) were selected to construct the risk signature. Blue square: HR < 1; red square: HR > 1; green bar: HR (95%CI)