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. Author manuscript; available in PMC: 2023 Sep 18.
Published in final edited form as: J Leukoc Biol. 2021 Jul 16;111(4):805–816. doi: 10.1002/JLB.2A1220-824R

FIGURE 4. Loss of hematopoietic cell lineages in the bone marrow of GATA2 deficiency patients.

FIGURE 4

Assessment of bone marrow cellularity and flow cytometric analysis of marrow from 34 patients with GATA2 deficiency and 16 healthy controls (HCs) were performed. Bone marrow cellularity was significantly decreased in GATA2 patients (A) as shown on scatter plot and in representative images of bone marrow biopsies from GATA2 patient and HC (200×, H&E stain). Flow cytometric analysis of marrow showed CD34-positive cells are significantly decreased in GATA2 patients (B), as are monocytes (C), plasmacytoid (PC) dendritic cells (D), NK cells (E), precursor B cells and mature B cells (F). Scatter plots with cell population values from GATA2 and HC marrows are displayed on top and representative flow cytometry plots from GATA2 and HC are displayed beneath with the indicated populations highlighted within boxes on the plots. ***, P < 0.001