Table 3.
Top 10 non-redundant drug combinations with potential synergistic effect.
| Rank | Overlap Score *(10−3) | Drug Combination |
|---|---|---|
| 1 | 89.4 | Vorinostat – Dorsomorphin dihydrochloride |
| 2 | 87.7 | PP-110 - Dorsomorphin dihydrochloride |
| 3 | 86.8 | Puromycin hydrochloride – Vorinostat |
| 4 | 86.4 | PP-110 - Vorinostat |
| 5 | 86.4 | PP-110 - TW 37 |
| 6 | 86.0 | Selumetinib – Dorsomorphin dihydrochloride |
| 7 | 85.1 | Selumetinib – Vorinostat |
| 8 | 85.1 | BMS-536924 - Dorsomorphin dihydrochloride |
| 9 | 84.7 | BMS-536924 - Vorinostat |
| 10 | 84.7 | TW37-Dorsomorphin dihydrochloride |
*The overlap score is calculated as the combined overlap of the DEGs of the two drug signatures with the input gene lists.