Probability of upgrading-free survival to ≥GG3 during AS of PCa after an MRI-guided confirmatory biopsy. Upper panel, overall probability of upgrading-free survival. Middle panel, probability of upgrading-free survival stratified by cancer-containing core type at confirmatory biopsy (black, negative systematic and negative targeted cores; blue, positive systematic and negative targeted cores; yellow, negative systematic and positive targeted cores; green, positive systematic and positive targeted cores). Lower panel, probability of upgrading-free survival stratified by GG at confirmatory biopsy (blue, no cancer; red, GG1; green, GG2). Sys, systematic biopsy.