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Omicron relies on TMPRSS2, and not cathepsin L or B, for entry into human intestinal organoids. (A and B) Replication of Delta (A) and Omicron (B) in CRISPR/Cas9-edited knockout clones deleted for the indicated genes. Groups were compared by two-way ANOVA. *P < 0.05. Error bars depict SEM. Each dot shows data from three individual organoid wells, whereby each time point represents three independent organoid wells.
