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. 2023 Sep 18;9(2):vead055. doi: 10.1093/ve/vead055

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© The Author(s) 2023. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Effects of amino acid mutations to E protein. The area plot at top shows the average effects of mutations at each site, and the heatmap shows the effects of specific amino acids, with x denoting the amino acid identity in the Wuhan-Hu-1 strain. See https://jbloomlab.github.io/SARS2-mut-fitness/E.html for an interactive version of this plot that enables zooming, mouseovers, adjustment of the minimum expected count threshold, and layering of stop codon effects on the site plot. See https://jbloomlab.github.io/SARS2-mut-fitness for comparable interactive plots for all SARS-CoV-2 proteins.