Figure 5. Distribution of azithromycin resistance-associated acrB mutations detected in Typhi genomes.

(a) Temporal distribution of acrB mutants. (b) Distribution of acrB mutants by genotype and mutation. The first acrB mutant appeared in Samoa in 2007. Other mutants have appeared independently across a range of genetic backgrounds, largely in South Asian countries, but remain at low prevalence levels overall (see Figure 2). Country of origin is coloured as per inset label.