Locations on the chromosome include previously inaccessible regions such as telomeres, centromeres and pericentromeres, satellite DNA, and segmental duplications. A complete genome, such as T2T-CHM13, closes gaps in the assembly and corrects misassemblies, including copy number (CN) errors. Diverse samples of the human population are needed to differentiate between common and rare variants, to comprehensively catalog this variation and to find new disease associations.