Table 4.
Associations between age, gender, smoking, TNM staging, tumor grade, lymph node invasion and tumor size, and fold change of BMI1 and miR-330-3p in CRC patients
| Variables | Number | BMI1 Mean ± SD |
P. value | miR-330-3p Mean ± SD* |
P. value |
|---|---|---|---|---|---|
|
Age
≤50 >50 |
- 61 21 |
- 4.39 ± 2.93 2.78 ± 1.17 |
- 0.12 |
- 0.31 ± 0.24 0.33 ± 0.12 |
- 0.238 |
|
Gender
Male Female |
- 52 30 |
- 3.90 ± 2.55 4.11 ± 2.93 |
- 0.62 |
- 0.31 ± 0.22 0.33 ± 0.21 |
- 0.61 |
|
Smoking
No Yes |
- 37 45 |
- 3.51 ± 2.51 4.36 ± 2.78 |
- 0.19 |
- 0.37 ± 0.23 0.27 ± 0.20 |
- 0.04 |
|
TNM staging
Low(I/II ( High(III/IV) |
- 39 43 |
- 1.84 ± 0.47 5.92 ± 2.35 |
- 0.001 |
- 0.52 ± 0.15 0.13 ± 0.04 |
- 0.001 |
|
Grade
I/II III/IV |
- 76 6 |
- 3.82 ± 2.52 6.01 ± 3.91 |
- 0.08 |
- 0.33 ± 0.22 0.15 ± 0.06 |
- 0.09 |
|
Lymph node invasion
Negative Positive |
- - 17 65 |
- - 1.81 ± 0.27 4.54 ± 2.74 |
- - 0.001 |
- - 0.59 ± 0.17 0.25 ± 0.17 |
- - 0.001 |
|
Tumor size (cm)
≤5 >5 |
- 4 78 |
- 2.39 ± 1.34 4.06 ± 2.71 |
- 0.16 |
- 0.46 ± 0.17 0.31 ± 0.22 |
- - 0.11 |
|
OB** test
Positive Negative |
- 70 12 |
- 4.23 ± 2.76 2.52 ± 1.49 |
- - 0.080 |
- 0.30 ± 0.21 0.42 ± 0.22 |
- - 0.018 |
*SD: standard deviation; **OB: Occult Blood