Table 2.
Multivariate Logistic Regression Model of Severity Outcomes Adjusted for Demographics and Comorbidities: 1 January 2020 to 30 June 2022 for n = 2 453 799
| Covariables | Life-Threatening Condition (Yes, 54 932; No, 2 398 867) OR (95% CI) |
P Value | Hospitalized Condition (Yes, 220 353; No, 2 233 446) OR (95% CI) |
P Value |
|---|---|---|---|---|
| AID/IS status | ||||
| AID only | 1.13 (1.09–1.17) | <.001 | 1.21 (1.19–1.24) | <.001 |
| IS only | 1.27 (1.24–1.30) | <.001 | 1.19 (1.17–1.21) | <.001 |
| AID + IS only | 1.35 (1.29−1.40) | <.001 | 1.31 (1.28–1.34) | <.001 |
| Demographics | ||||
| Age | 2.84 (2.81–2.88) | <.001 | 1.94 (1.93–1.95) | <.001 |
| Body mass index | 1.08 (1.07–1.09) | <.001 | 1.10 (1.09–1.11) | <.001 |
| Gender | ||||
| Female | 1 [Reference] | 1 [Reference] | … | |
| Male | 1.51 (1.48–1.53) | <.001 | 1.29 (1.28–1.30) | <.001 |
| Race | ||||
| White | 1 [Reference] | 1 [Reference] | … | |
| Other/Unknown | 1.20 (1.16–1.25) | <.001 | 1.18 (1.16–1.20) | <.001 |
| Black or African American | 1.37 (1.33–1.40) | <.001 | 1.77 (1.75–1.80) | <.001 |
| Asian | 1.32 (1.24–1.40) | <.001 | 1.35 (1.31–1.40) | <.001 |
| Ethnicity | ||||
| Not Hispanic or Latino | 1 [Reference] | 1 [Reference] | … | |
| Hispanic or Latino | 1.18 (1.13–1.22) | <.001 | 1.39 (1.36–1.41) | <.001 |
| Smoking status | ||||
| Nonsmoker | 1 [Reference] | 1 [Reference] | … | |
| Current or former | 1.37 (1.34–1.40) | <.001 | 1.61 (1.59–1.63) | <.001 |
| Comorbidity | ||||
| Cardiovascular diseasea | 1.69 (1.66–1.73) | <.001 | 1.67 (1.65–1.69) | <.001 |
| Dementia | 2.22 (2.16–2.30) | <.001 | 1.99 (1.94–2.04) | <.001 |
| Chronic pulmonary disease | 1.23 (1.21–1.26) | <.001 | 1.29 (1.27–1.30) | <.001 |
| Liver disease, mild | 1.34 (1.30–1.38) | <.001 | 1.25 (1.22–1.27) | <.001 |
| Liver disease, severe | 3.05 (2.89–3.23) | <.001 | 2.33 (2.23–2.42) | <.001 |
| Kidney disease | 1.77 (1.73–1.81) | <.001 | 1.88 (1.86–1.91) | <.001 |
| Cancer | 1.45 (1.41–1.49) | <.001 | 1.24 (1.22–1.26) | <.001 |
| Metastatic cancer | 3.31 (3.17–3.46) | <.001 | 2.19 (2.12–2.26) | <.001 |
| Type 2 diabetes mellitus | 1.32 (1.29–1.35) | <.001 | 1.46 (1.44–1.48) | <.001 |
| Human immunodeficiency virus | 1.24 (1.12–1.38) | <.001 | 1.26 (1.19–1.33) | <.001 |
Abbreviations: AID, autoimmune disease; CI, confidence interval; IS, immunosuppressant; OR, odds ratio.
Cardiovascular disease: myocardial infarction, congestive heart failure, peripheral vascular disease, stroke.