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. 2023 May 15;77(6):866–874. doi: 10.1093/cid/ciad265

Table 2.

Mean and 95% Confidence Interval of Change in Cognitive Domain z Scores at Week 48

Cognitive Domain Total (N = 190) Arm A
(Dual-Placebo)
(n = 63)
Arm B
(DTG + Placebo)
(n = 67)
Arm C
(DTG + MVC)
(n = 60)
Attention/working memory 0.32 (0.21 to 0.43) 0.24 (0.04 to 0.43) 0.44 (0.28 to 0.60) 0.28 (0.07 to 0.50)
Executive function 0.25 (0.15 to 0.35) 0.26 (0.05 to 0.46) 0.24 (0.07 to 0.41) 0.25 (0.09 to 0.42)
Fine motor skills 0.25 (0.16 to 0.35) 0.38 (0.22 to 0.54) 0.19 (0.03 to 0.35) 0.18 (0.00 to 0.37)
Speed of information processing 0.23 (0.09 to 0.37) 0.17 (−0.09 to 0.44) 0.36 (0.13 to 0.60) 0.14 (−0.12 to 0.40)
Verbal learninga 0.23 (0.07 to 0.39) 0.01 (−0.28 to 0.30) 0.17 (−0.09 to 0.43) 0.53 (0.26 to 0.79)
Verbal memorya 0.13 (−0.14 to 0.40) −0.15 (−0.62 to 0.32) −0.08 (−0.57 to 0.42) 0.64 (0.24 to 1.04)

Abbreviations: DTG, dolutegravir; MVC, maraviroc.

Verbal learning and verbal memory improved more in the DTG + MVC arm than in the dual-placebo arm (both P values = .01) or the DTG + placebo arm (verbal learning P = .06, verbal memory P = .03).