Table 2.
Cognitive Domain | Total (N = 190) | Arm A (Dual-Placebo) (n = 63) |
Arm B (DTG + Placebo) (n = 67) |
Arm C (DTG + MVC) (n = 60) |
---|---|---|---|---|
Attention/working memory | 0.32 (0.21 to 0.43) | 0.24 (0.04 to 0.43) | 0.44 (0.28 to 0.60) | 0.28 (0.07 to 0.50) |
Executive function | 0.25 (0.15 to 0.35) | 0.26 (0.05 to 0.46) | 0.24 (0.07 to 0.41) | 0.25 (0.09 to 0.42) |
Fine motor skills | 0.25 (0.16 to 0.35) | 0.38 (0.22 to 0.54) | 0.19 (0.03 to 0.35) | 0.18 (0.00 to 0.37) |
Speed of information processing | 0.23 (0.09 to 0.37) | 0.17 (−0.09 to 0.44) | 0.36 (0.13 to 0.60) | 0.14 (−0.12 to 0.40) |
Verbal learninga | 0.23 (0.07 to 0.39) | 0.01 (−0.28 to 0.30) | 0.17 (−0.09 to 0.43) | 0.53 (0.26 to 0.79) |
Verbal memorya | 0.13 (−0.14 to 0.40) | −0.15 (−0.62 to 0.32) | −0.08 (−0.57 to 0.42) | 0.64 (0.24 to 1.04) |
Abbreviations: DTG, dolutegravir; MVC, maraviroc.
Verbal learning and verbal memory improved more in the DTG + MVC arm than in the dual-placebo arm (both P values = .01) or the DTG + placebo arm (verbal learning P = .06, verbal memory P = .03).